Human Lymphocytes Exposed to Co Irradiations and I Decays

Human Lymphocytes Exposed to Co Irradiations and I Decays Chapter 1: Introduction 1.1. Microdosimetry Problem statement Nuclear medicine and molecular imaging use unsealed radionuclides for diagnostic or therapeutic purposes. In targeted radiotherapy, the aim is to address tumor cells using suitable radiopharmaceuticals and achieve a high dose deposition inside the target structures. â€Å"Macrodosimetry† generally entails estimating the dose effect in organs (or dimensions of at least some millimeters) and is outlined in detail by the Medical Internal Dose (MIRD) Committee, the U.S. Society of Nuclear Medicine and the International Commission of Radiological Protection (ICRP) [1]. Microdosimetry therefore entails estimating the dose absorbed in microscopic objects such as cells. Dose deposition in cells can originate from extracellular media, intracellular uptake in a single cell and from surrounding cells. As an alternative to characteristic photon emissions,radionuclides decaying by electron capture or internal conversionmay undergo a process known as the Auger effect. In the Auger effect, an electron from an outer shell fills the lower electron vacancy, but the energy released in the process is transferred to another orbital electron. This electron is then emitted from the atom instead of a characteristic X-ray [2]. The emitted electron is called an Auger electron,with ranges in tissue typically at the micro- or nanometer level [3].Their unique property of depositing significant amounts of energy in minute volumes around the decay site opens up the possibility of using them as microscopic probes to study fundamental questions regarding the interaction of radiation with cells. 123I is used mainly in nuclear medicine because of its ideal ÃŽ ³-ray energy (159 keV) and relatively short half-life (13.2 h). The decay of 123I is, however, also associated with the production of Auger electrons. These low energy particles (4]. Knowledge of the absorbed dose is required for evaluation of the observed biological effects and to predict or compare the effectiveness of different radiation modalities. However, direct dose measurements in cells are impossible due to the small cellular dimensions [5]. According to the stochastic character of all of the decay processes, a large number of pathways exist by means of which a radioactive particle can decay and the excited atom can de-excite, i.e. each initial inner shell vacancy may cause a different number of Auger electrons to be emitted resulting in a more or less broad distribution of differently charged ions. Because these electron transitions and particle interactions are random processes, the Monte Carlo technique is an appropriate tool for the simulation of Auger emissions and electron spectra, as well as a feasible method to obtain correct absorbed dose values under consideration of all irradiation aspects like geometry and activity distributions [5],[6], [7]. Bingham et al. found that the dose delivered to the cell nucleus is underestimated by a factor of 7.4 for 123I in cells with nuclear radius of 4 ÃŽ ¼m and cell radius of 12 ÃŽ ¼m when compared to conventional electron dosimetry, indicating the need of developing dosimetr ic calculations for electrons emission at a cellular level [8]. Geant4 is an open source Monte Carlo (MC) toolkit, based on object orientated programming rules using the C++ language, which provides functions for simulating the passage of particles through matter [9]. The code is freely downloadable from the Geant4 web site. Detailed descriptions of the toolkit design and the physical fundamentals may be found in the â€Å"Geant4 User’s Guide for Application Developers† and the â€Å"Physics Reference Manual† [10], [11]. Besides the fact that it is entirely open-source and freely available to all users, the main advantage of this toolkit is its openness to modification and extensions. Originally Geant4 comes from high-energy physics but it also provides low-energy physics processes necessary for medical applications. Users may construct stand-alone applications or applications built upon another object-oriented framework. In either case the toolkit offers support from the initial problem definition to the production of results and graphics for publication. At the heart of Geant4 is an abundant set of physics models to handle the interactions of particles with matter across a very wide energy range. Data and expertise have been drawn from many sources around the world,and in this respect Geant4 acts as a repository which incorporates a large part of all that is known about particle interactions[12]. All aspects of the simulation process have been included in the toolkit: the geometry of the system, the materials involved,the fundamental particles of interest, the generation of primary events, the tracking of particles through materials and electromagnetic fields, t he physics processes governing particle interactions, the response of sensitive detector components, the generation of event data,the storage of events and tracks, the visualization of the detector and particle trajectories, and the capture and analysis of simulation data at different levels of detail and refinement. 1.2. Objectives Aims The level of biological effects of certain radiations is not always directly proportional to the dose they impart. Since the delivered dose on a cellular level is not directly measurable using current instrumentation, scientists and physicians have developed correlations between the biological response and the exposed dose through experiment and theory of atomic physics. An alternative method of predicting the delivered dose in a cell is by using Monte Carlo simulations. These simulations however, have to describe the biological composition and geometries of the material as accurately as possible, as well as the interactions of different particles with the material and can therefore result in complex codes and extremely long computation times. In our study, the aim was to determine (through experiments and using Monte Carlo simulations) the relative biological effectiveness[1] (RBE) of isolated and stimulated human lymphocytes exposed to 60Co irradiations and 123I decays. The first phase of experiments was the exposure of 3 different types of cellsto a 60Co-teletherapy unit. The proposed cell lines were: human lymphocytes, rat brain endothelial cells(bEND5, a cell with high radiosensitivity) andChinese hamster ovarian cells (CHO-K1, a cell with low radiosensitivity). The cells were exposed to graded doses of 60Co ÃŽ ³-radiation, after which they were cultured and the micronuclei formations in binucleated cells were used to analyze the effects of ÃŽ ³-radiation on the cell types. The second phase of experiments was the exposure of a known number of isolated and stimulatedhuman lymphocytes to certain activities of 123I for a discrete amount of time. The thymidine analogue 5-[123I]-iodo-2-deoxyuridine (123IUdR) was prepared and used to incorporate123I into theDNA of human lymphocytes. This was done such that the radionuclide could be transported across the cell and nuclear membrane to permit the deposition of Auger and Coster-Kronigelectrons in close proximity to cellular DNA. After exposure, the samples werecultured to express residual radiation damage. The cellular damage was quantified by numerating the micronuclei (MNi) frequency in binucleated (BN) cells.The experiments were done at iThemba LABS under the supervision and guidance of Prof. Slabbert and Philip Beukes. The experimental work followed the same approach as that of Slabbert, et al[13]. In the study they focused on the targeting and accumulation of 123I in human lymphocytes and CHO-K1 (a Chinese hamster ovary cell line). They found that the combined effect of intracellular and extracellular disintegrations of 123I is about 3.7 times more potent to lymphocytes compared to when the disintegration of the radionuclide is restricted to only the extracellular medium, among other results. It was concluded that this enhancement is due to the short range Auger electrons emitted by the isotope. Next, we wished to recreate the above experiments through Monte Carlo simulations and thereby determine as accurately as possible the absorbed energy and dose due to the irradiations,specifically the energy and dose deposited by Auger electrons produced during the decay of 123I. We will make use of a Monte Carlo based simulation code Geant4. The code must be mastered and used to simulate the scenarios mentioned above. We attempted to simulate the above 60Co exposures. This simulation was an investigation into the irradiation of a macroscopic volume by a radioactive source. The geometry was set up to replicate the experimental setup with regards to the source location and type, collimation, build-up and backscatter, the Petri dish and cellular media. The individual cells were not used as detectors, only the effective volume in the Petri dish. The energy and the dose deposited by the 60Co source (ÃŽ ³-rays, primary and secondary electrons) was then quantified by the Monte Carlo simulation. Our main endeavor was to simulate the energy deposition from the decay of 123I within a cell using Geant4. Basically, a geometry representing a biologicalcell (with the same density, etc. as the proposed lymphocytes) was created as a detector to measure the dose, energy and particles traversing it due to a radionuclide prone to emit Auger electrons, i.e. 123I. A similar simulation was performed by Bousis, et al (2012), using their in-house Monte Carlo code [14]. More advanced simulations are the calculation of DNA strand breaks due to direct and indirect effects of Auger electrons as was demonstrated by Raisali, et al (2013), which werehowever not attempted in this investigation [15], [16], [17]. Furthermore, an empirical formula relating the activity(and consequently the absorbed dose) to the biological response was determined. The curveswere compared to other dose-response curves from literature, thereby indicating if the simulations are a viable option for predicting accurate dose depositions. We could then calculate the RBE values from our dose-response curves and compare them to values available in literature. Finally, we aimed to determine the accuracy and feasibility of Geant4 as a simulation toolkit for medical and radiobiological purposes. To this end we considered the practicality, effort and time spent using Geant4, as well as by the comparison of RBE values and dose-response curves. Geant4 is an advanced, extensive and comprehensive simulation toolkit. Its advantage over similar packages with regards to availability, artistic and geometric freedom, physics models and materials libraries and openness to modification are undeniable. It is a very powerful simulation toolkit and can be used in a large number of areas of expertise as is shown by the examples supplied alongside the toolkit. [1]RBE values indicate the effectiveness of two radiation qualities to produce a certain biological response.

Flappers Essay example -- American History Essays

Flappers When one thinks of flappers, the first thing that comes to mind is the image of a woman dressed much like Julie Andrews in Thoroughly Modern Millie, bobbed hair, fringed low-waisted dress, flat-chested and highly made up face. This, though a stereotype is close to the truth. In the 20’s after the first world war women’s roles in society began to change, primarily because they started becoming more independent – both in their dress and action. They started to defy what was considered to be appropriate feminine behavior and along with those actions came new fashions. The sleek, boyish look became popular and women began to wear lower waistlines, higher hemlines, sleeveless dresses that showed off their arms, long strands of pearls and rolled down pantyhose to show their knees. Women who had larger breasts even went so far as to bind them down to fit into the flat-chested ideal of beauty. The â€Å"in† look now was boyish, much in contrast to the feminine big skirted, shirtwaisted dresses of their mothers’ age. Women began to gain the independence and social liberties that men had always possessed, they wanted to physically display their newly gained freedoms. Short hair, first as a bob, later as a slicked down â€Å"shingle† that curled above the ears emphasized the new androgynous look women were trying to obtain. These â€Å"modern† women asserted their independence by going out dancing, moving to the city alone, drinking even during prohibition, flirting and having love affairs. After gaining so much independence in World War I when men were away across the ocean, many women resisted the idea that they should now return to the kitchen, the rise of the flapper came out of this new concept of feminism and... ...elf sufficient, sexy, and powerful were all so appealing to the women who had been oppressed for years in the past that society had to change entirely to accommodate them. Sources http://home.earthlink.net/~rbotti/ Flapper Station, information on flapper culture, ties to sites with pictures of vintage flapper clothing http://www.geocities.com/flapper_culture/ Flapper Culture, first person articles about the age, literary ties in the age and many details about the decade of decadence. http://home.earthlink.net/~dlarkins/slang-pg.htm The Internet Guide to Jazz Age Slang, jazz dictionary for terms like â€Å"applesauce† and â€Å"petting party† Mowry, George Edwin, The Twenties: Fords, Flappers, and Fanatics, Englewood Cliffs, NJ, Prentice-Hall, 1963 Melman, Billie, Women and the Popular Imagination in the Twenties: Flappers and Nymphs, Macmillan Press, 1988

Essay --

The State of Israel is one of the youngest countries in the West Asian region. Since the late 19th centuries Jews from different parts of the world emigrated to the land of their forefathers towards creating a homeland, in an area that was predominantly inhabited by Arab Palestinians for centuries. Since its inception, the Jewish immigration or aliya has been in the process of developing its own identity and this effort is reflected in its constant search for common roots or to seek a unified Jewish identity for a people after two millenniums of Diaspora. Because of historical reasons and circumstances, Zionism had never accepted the Diaspora as a valid place for the Jews to be their home. The role of the past in the construction and legitimation of various ethnic and national movements raises importance of archaeology. This is valid for Zionism and its profound interests in historical sites and artefacts grew out of its search for Jewish national identity. Archaeology has been used by different nations as a political tool for the construction of their national identities. There are numerous examples from all over the world such as Soviet Union, Spain, Italy, Bulgaria, Ireland, Romania, Georgia, Belgian, Portugal, Norway, Albania, Germany, England and Japan etc. where archaeology was used in process of nation building. Archaeology in West Asian and North Africa region has been politicized successively through the efforts of colonialists and during the process of nation state building. Iraq, Israel and Egypt has been used archaeology in the process of nation-building. Archaeological evidences have been used in Israel to create a unified idea of the state through the presentation of the past, its connection to the present, and its... ...60s. The relationship that politicians and generals forged with archaeology was perhaps too intimate. During 1963 to 1965 Yigael Yadin ( first as Chief of Staff and then as a professor of archaeology) conducted excavations at Masada, which received personnel, funding and equipment support from a vast number of national and international Jewish organizations, as well as the Israeli army. The phrase "Masada shall not fall again" became a slogan for protecting the State of Israel that has become popular even outside the country. Furthermore the place and story became part of the socialization process and rituals of youth organizations and the Israeli army. Later it became the revealed site for the swearing in ceremony for the Israel Defence Forces (IDF). After prolonged efforts, the peace process facilitated Masada being declared a UNESCO World heritage Site in 2001.

Mary Shelley present Frankenstein Essay

‘Frankenstein’ was written in 1812 by a woman called Mary Shelley, at the age of 19, this shows that she is very intelligent because to write such a novel with so much understanding at a very young age shows that she was a dedicated female author who studied very hard. At first when I heard of the novel ‘Frankenstein’ I straight away thought without any doubt that it was a man who wrote this novel, because firstly it was a horror story so that instantly clicked in my mind to think that it was a man but I was very shocked to find out that the author of the novel was actually a women. This seemed very unusual to me because firstly at that time female authors were less well thought of than male authors and also even if female writers wrote books you would expect them to be all flowery and cosy type but for a women to write a novel with such imagination, creativity and devilish thoughts seemed very unusual with the basic fact that she was a women. This again showed that she was very intelligent. She also didn’t put her name on the book for 13 years, this was because of the fact that mentioned earlier about female writers being less thought of than male writers. I believe that she done this because during that time there might have been a lot of sexism and she believed that if she put her name on the book than a lot of people may not have bought it because she was a female and when she did put her name on the book I am sure that a lot of people were shocked to hear that it was written by a women. She probably played a vital part in raising the confidence of female writers and broke the deadlock for all female authors. The novel was about a young ambitious scientist who is keen to prove that he can create life. The scientists name is Victor Frankenstein. He accomplished his mission but all his dreams about this being were crushed when he realised what a monster he had created. Frankenstein ran away from the monster and left it to a life of loneliness. The monster learned how to talk and read and soon tracked down Victor Frankenstein. After being treated badly by humans the monster had one thing on his mind which was revenge. The novel starts with a letter from Robert Walton an explorer, to his sister. He is preparing to go on his way to his desired destination the North Pole. He is a very ambitious man and he wants to go on this expedition because no man has ever set foot there. Walton writes: â€Å"Never before imprinted by the foot of man† Walton also wants to be the man who discovers the route to the North Pole because at that time there was no route to this area of the world. This shows how desperate he was to go there and his ambitiousness. He trained his body for the expedition and Walton tells us: ‘I voluntarily endured cold, famine, thirst and of want of sleep’ This proves his determination and how serious he was about his venture.

Industrialised Countries Essay

‘Newly industrialised countries have been, and continue to be, the driving force of globalisation’ To what extent do you agree with this statement Globalisation can be seen as the increased flow of goods, services and information across countries, and it is driven by rapid technological growth and increased connectivity between countries of the world. It also establishes and maintains economic and political relations between these countries. Some of the factors that have affected globalisation include technological innovation as it had made transport and communication around the world easier, trade has also played an important role in encouraging globalisation. Trade between countries in the developed world and the developing world has specifically been the biggest driving force of globalisation. Newly industrialised countries or NIC’s are countries whose economies have not yet reached first world economic status but their economic growth are still increasing more than other developing countries. NIC’s are switching their current agriculture-based economy into a more industrialised, urban economy. Current NICs include China, India, Brazil, Malaysia, Mexico, South Africa, Philippines, Thailand and Turkey. The average growth rate between these countries is approximately 7.6% compared to the world average of 3.7%. The first group of NIC’s came from the Asia area, they included Taiwan, South Korea, Hong Kong and Singapore. They called these the Asian Tigers. The Asian Tigers were notable for maintaining exceptionally high growth rates (in excess of 7% a year) and rapid industrialization between the early 1960s and 1990s. By the 21st century, all four have developed into advanced and high-income economies. There are several factors that make Newly Industrialised countries the driving force of globalisation. Firstly, most newly industrialised countries have a large population; this makes the countries more attractive for investment as these countries have lots of cheap labour. Therefore, these countries seem more attractive to TNC’s as they can make more profits when the cost of labour is cheap. A Transnational Corporation or a TNC is a privately owned company that is based in 2 or more countries. They take advantage of the NIC’s cheap labour and large growth rate. For instance Toyota is one of the world’s leading car manufacturers and is the third largest in the world. Although based in Japan, Toyota produces most of its cars in its transplants in Georgetown, Kentucky, and Burnaston and Derbyshire.

Early Childhood Essay

Every child is unique in terms of life experiences, developmental readiness, and cultural heritage. A high quality early childhood program should provides a safe and nurturing environment, which promotes physical, social, emotional, language and cognitive development will ensure a positive continuation of the child’s education process. Kindergarten for children is very important. Most parents and children are excited about this stage in life for their child, as well as children might be a scared or nervous. Kindergartens are still mastering new physical skills. They are more able to move their body the way they wants to and, most likely, can run like the wind. Throughout the year kindergarten children will show a number of new physical skills, some are more important than others to help make her kindergarten year a highly successful learning experience. Kindergarten is the year to get used to the routine of school, and the idea of being accountable to a new authority figure and to make new friends, but it’s a crucial year to build the foundation for learning. Kindergarten learns differently, some may learn hands on, or visual. Kindergarten are at the most important stage in life so it is up to the educators to make a difference that can help them in the long so they are able to reach the next grade level as well as overcome any milestones that they may reach throughout their education. First, the classroom is loving, kind, caring, sharing, and motherly to all the children just like my own. The way I envision my classroom is that as you walk in the door you see art and picture of children playing and eating and doing different thing that supports the area such as dramatic play would be children in doctor jackets or something in that nature. The classroom has warm colors around it for each season. Each area of the classroom would be label with such as blocks would be block area, art, dramatic play, water area, science, literacy, etc. The children cubbies are label with their name and picture so they are able to recognize themselves. The library has age appropriate books for the children. The classroom should off the children art and learning. If there is a theme in the classroom the room will represent that specific theme. Each child is at a table that is color coded that will identify each table as a group, each table seats about 3-4 students depending on the class size. Each child has a portfolio so children are able to see their progress throughout the year. The classroom is based on play and material and the children have a teacher child relationship. While planning the curriculum I will provide free play that will allow children their individually time to choose an area of involvement (Eliason, Jenkins 2012). An effective curriculum children should be active and engaged, the goals are clear and shared by all, evidence based, the valued content is learned through investigation, play, and focused, intentional teaching (Eliason, Jenkins 2012). The curriculum builds on prior learning and experiences and is comprehensive and most important benefit the needs of the children (Eliason, Jenkins 2012). Curriculum should be planned around the developmental needs of the children in my classroom (Eliason, Jenkins 2012). Curriculum will builds upon what children already know and are able to do to enable them to connect new concepts and skills. The National Association for the Education of Young Children (NAEYC) urges that as a teacher my curriculum is thoughtfully planned, challenging, engaging, developmentally appropriate, culturally and linguistically responsive, comprehensive and likely to promote positive outcome for all children (Eliason, Jenkins 2012). While planning the curriculum I will provide free play that will allow children their individually time to choose an area of involvement (Eliason, Jenkins 2012). The experiences should be developed to help the young children in the classroom to help improve their skills in problem solving, thinking, reasoning, and creating (Eliason, Jenkins 2012). The National Association for the Education of Young Children states that high quality, developmentally appropriate programs should be available for all children. A separate statement of the NAEYC divides the concept of appropriateness into two aspects: age appropriateness and individual appropriateness. Philosophies that reflect how I envision my classroom and curriculum are Friedrich Froebel. Friedrich Froebel was a German educator of the nineteenth century who developed an Idealist philosophy of early childhood education. He established kindergarten and education for four and five-year-old children. Kindergarten is now a part of education worldwide. Friedrich Froebel was born in the small town of Oberwiessbach, Germany in 1782. His mother died when he was a baby (Froebel, 2011). His father remarried, but Froebel never liked his stepmother. His feeling of rejection and isolation remained with him for life. This had a strong effect on his theory of early childhood education. He believed the kindergarten teacher should be loving, kind and motherly (Froebel, 2011). Froebel studied at the University of Jena for a short time. In 1805, while studying architecture in Frankfurt, he was persuaded to become a teacher by the model school at Frankfurt. Friedrich Froebel changed the way we think about early childhood education. He designed balls, wooden blocks, tiles, sticks and rings to demonstrate that children learn by playing. Known around the world as the Froebel Gifts , these objects were an important part of his Kindergarten (Froebel, 2011). Froebel also included in his kindergarten philosophy the study and nuture of plants in a garden for stimulating children’s interest in nature. He felt it was important for children to grow up in harmony with nature. The Froebel Gifts have been widely imitated and adapted by educators and toys makers. Because of Froebel my classroom will have the right material to that I am able to teach my children with the right material so they can play and learn at the same time. He felt that the teacher should be loving caring and motherly and I feel that I am that way in the classroom as well. â€Å"Treat peoples how you want to be treated† and that’s how I feel as a teacher. Treat other children how I would want my children to be treated. Having that motherly character can also make it easier for a child to be more comfortable in the classroom especially if it the first time being away from the parents. Being that Froebel knew what it was like losing his mother and not liking his stepmother he knew what it was like to feel neglect and isolated so he incorporated that in with teaching and realized that no child should ever feel that way. Froebel’s kindergarten used free play, games, songs, stories, and crafts to stimulate imagination while developing physical and motor skill. In most classrooms free play is welcomed as well as games, stories, songs, and craft that will encourage children motor skills as well as solving problems. The kindergarten program was designed to meet children’s needs for physical activity, sensory awareness, creative expression, exploration of ideas and concepts, the pleasure of singing, and the experience of living among others. His educational approach was for â€Å"self-activity,† the idea that allowed the child to be led by his own interests and to freely explore them. Children are more independent and they want to explore new things on their own. Children become aware of numbers early in life, because of daily experience involve various use of numbers. Math is more than learning about numbers and how to add, subtract multiply and divide (Eliason, Jenkins 2012). The National Council for Teachers of Mathematics suggests 10 curriculum standards. The standards provide a guide in mathematics curriculum planning ; content standard are numbers and operation, algebra, geometry, measurements, and data analysis and probability. The process standards are problem solving reasoning and proof, communication, connection and representation (Eliason, Jenkins 2012). The standard gives an overview of math content and process for prekindergarten through the second grade(Eliason, Jenkins 2012). While teaching math to the children I will also incorporate promotes such as blocks, legos, cheerios, etc so that the children are able to see what they are doing visually . At the end of the year children will be able to understands one-to-one correspondence, sorts and classifies objects according to common characteristics, recognize and create patterns. (e.g. red, blue, red, blue or boy, girl, boy, girl), understand simple bar graphs and interpret how they help us gather information, count to 100, identify and print numbers 1-20, identify and draw basic shapes such as rectangle, square, circle and triangle. Reading is a communicative art that involves recognizing and understanding words(Eliason, Jenkins 2012). Children cannot read with understanding and comprehension something they don’t have the background knowledge about. Learning to read takes time, patience, desire, and readiness (Eliason, Jenkins 2012). Kindergarten is a year of discovery in reading and literacy. Child will learn to recognize simple words in print, including his own name and those of his classmates. Letter-sound correspondence, phonemic awareness, sight words recognition, rhyming and words families and concepts about print are the areas in which your child will expand his knowledge this year. By the end of the year some kindergartners will even be reading a little bit. Kindergarten science explores topics that are meaningful to students and can be applied to everyday life. Children will learn about good health habits, including nutrition and an introduction to dental hygiene. Children will spend time learning the process of inquiry as we learn about the five senses. Children will be able to collect information , observation, and data record information while exploring science projects. We will observe outside, take field trips, walks, and be able to talk about what we see. We will explore cause and effect. Science will be integrated into everyday activities including cooking projects Fine Arts are any art form. For example, painting, sculpture, architecture, drawing, or engraving that is considered to have purely aesthetic value (Encarta, 2004). The arts can open the minds of students in ways mere reading and writing will never be able to accomplish. Teaching through arts helps students experience concepts rather than simply discussing or reading it or have it read to them. This approach is consistent with educational theories that highlight the importance of reaching multiple learning styles or intelligences (Jacobs, 1999, p. 2). By working through the arts, instead of about the arts, the students’ educational experience will be achieved in a different way than just teaching the standard style of learning. Education of art helps students develop creativity, self-expression, analytical skills, discipline, cross-cultural understandings, and a heightened appreciation for the arts† and that â€Å"students who develop artistic expression and creative problem solving skills are more like to succeed in school. An activity that I would teach would be fine art such would be painting. Friedrich Froebel, the father of kindergarten, believed that young children should be involved in both making their own art and enjoying the art of others. Children will have a sheet of paper and would be able to pick two different colors out of four. I would allow them to chose if they want to finger paint, or use a paint brush. Once children have made their decision they would be able to self express.. Washington state standard for Art is through dance, music, theatre, and visual arts provide detailed recommendations and guidance for K–12 arts education. These documents include: Washington State K–12 Arts Learning Standards (one document encompassing all four arts disciplines—dance, music, theatre, and visual arts). Another activity would be science. We would see how long it takes an ice cube to melt. The Washington State K-12 Science Standards is a detailed document describing what all students are expected to know and be able to do at each level of our educational system in the area of science. The purpose of these standards is to provide strong support for students, parents, teachers, and the broader community by guiding the alignment of the school curriculum, instruction, and assessment at local and state levels. To accomplish this purpose it is essential to use this document in the following ways: Those responsible for curriculum alignment should refer to this document in selecting or developing instructional materials that enable students to acquire core conceptual knowledge and abilities in science. Those responsible for assessment alignment at the local and state levels should refer to this document in selecting and/or developing assessment tools and rubrics that measure student achievement of the core content in these standards. Those responsible for instructional alignment should refer to this document in designing classroom instruction and professional development of teachers to ensure that achieving these core content standards is a priority. It is also important to point out what the standards. In conclusion early childhood program should provides a safe and nurturing environment, which promotes physical, social, emotional, language and cognitive development will ensure a positive continuation of the child’s education process. References. â€Å"Friedrich Froebel (1782-1852) – Biography, Froebel’s Kindergarten Philosophy, The Kindergarten Curriculum, Diffusion of the Kindergarten. † Education Encyclopedia. StateUniversity. com. < http://education. stateuniversity. com/pages/1999/Froebel-Friedrich-1782-1852. html > 21 Dec. 2010. Froebel. (2011, April 04). † Education Encyclopedia. StateUniversity. com. < http://education. stateuniversity. com/pages/1999/Froebel-Friedrich-1782-1852. html > 21 Dec. 2010. Eliason, C. F. , Jenkins, L. (2012). A practical guide to early childhood curriculum (9th ed. ). New Jersey: Pearson Education, Inc. Cluff, D. (2005, October 6). The Importance of Fine Arts in the Classroom. Retrieved October 1, 2012, from http://ezinearticles. com/? The-Importance-of-Fine-Arts-in-the-Classroom&id=80061.

The Purchase of Paris Saint German Football Club by Qatar Sports Case Study

The Purchase of Paris Saint German Football Club by Qatar Sports Investments - Case Study Example It was an effective strategy because purchasing the football club by QSI was one way of showing national pride. The strategy motive was also the belief in the future growth of sports and enable PSG to achieve their big dreams. It was also an effective strategy for transforming the PSG into one of the biggest teams in the globe. Thus, placing people in power who have knowledgeable and effective skills about the sport would be significant for the success of the PSG club. The project also focused on the other argumentative side by revealing that to a smaller extent, the purchase of Paris Saint-German FC by QSI was not a good strategy. This was because selling the PSG FC to Qatar is one of putting the football club under risks. It was not a good strategy because it might be due to political interest and the aim for Qatar to achieve its business objectives. Lastly, the conclusion was included that provided a brief summary of the argumentative points presented in the project. In What Way i s the Purchase of Paris Saint-German Football Club by Qatar Sports Investments (QSI) a Good Strategy for the Company? Paris Saint-German FC is a qualified association football team, which is based in Paris, France. It was founded in 1970 by Saint-Germain and Paris football associations who joined and formed the association, which has been always representing Paris. PSG (Paris Saint-German) is an interesting football association across the globe. This team was bought by QSI during summer 2011, thus the French club has shocked many people because of its immense transfer expenditure. The Paris team has always been on the forefront and it has been in the competition record since it began its football association in 1974. PSG is among the teams that have won main European cup, and it became the major team in 1994 after it won the tournament cup. It was also ranked among the best leading teams in the UEFA tournament winners in 1998 and is currently ranked 16th in the IIHS (International F ederation of Football History & Statistics) and 46th in the UEFA team ranking. The purchase of PSG football club by Qatar is a good strategy for the company because of varied reasons. First, Qatar sports could be investing in football as one way of promoting Qatar business interest at large. For instance, Qatar will offer football companies a patronage pact to enhance their brand. Moreover, there is not team across the globe with higher interest than PSG. Since this football club was purchased by QSI, the club has greatly improved; thus shocked the world with its massive transfer cost. Many people are expecting a lot from QSI over the coming decades because they invest a lot; hence good for benefiting of the club. This is because it will enable the company to achieve their dreams of building a competitive team which will become among the best teams across Europe (Hytner, D. (September 11, 2012). The company owner has pledged to spend a lot in the coming years in order to enable the PSG to become the greatest football club across the globe. In addition, the purchase of PSG by QSI was a good idea because it is a big advantage to the company. This is because investing in the football club can enable them to develop a powerful team; thus contributing to increased performance level.